This week on the Big Picture, Jim and John discuss the broader implications of the historic Brexit vote. Last week the markets were in meltdown mode, but this week the markets bounced back like nothing happened. They begin with Prime Minister David Cameron, and why he put himself in this position. They discuss what is next for the UK, and which country or countries may be the next to leave the EU. They cover Article 50 of the Lisbon Treaty, and how the negotiations may proceed. They also discuss the investment implications of Brexit, and potential future instability. They also turn to Fed policy and whether it can now raise interest rates at all this year in light of the Brexit vote. Given the uncertainty ahead, Jim talks about a barbell approach to investing this year.